PW01-001 – Pyrin-PSTPIP1 relation during cell migration

نویسندگان

  • ZY Akkaya
  • B Balci-Peynircioglu
  • A Cetinkaya
  • N Purali
  • E Yilmaz
چکیده

Introduction MEFV (MEditerranien FeVer) gene mutations cause Familial Mediterranean Fever (FMF). This gene encodes a protein termed as Pyrin, which appears to play an important role in the inflammatory pathways. It is far characterized that Pyrin, which is expressed in neutrophils, interacts with PSTPIP1 and actin proteins. In previous studies PSTPIP1 has been shown to interact with cell migration proteins and actin polymerization is a main force driving neutrophil migration. Therefore, we hypothesized that Pyrin can play role in cell migration through the interaction with actin and PSTPIP1.

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2013